RECOGNITION OF SHOCK AT AN EARLY SATGE and Management ,DR.D.K.JHA,M.D.,Pediatrician and Pediatric Pulmonologist,Delhi

RECOGNITION OF SHOCK AT AN EARLY SATGE and Management ,DR.D.K.JHA,M.D.,Pediatrician and Pediatric Pulmonologist,Delhi

Assessment of hemodynamic conditions is most important in the management of critically ill patients

It is most important to pick up the condition of compensated shock and start treatment

Pediatric patients go into the stage of decompensated shock a bit late in comparasion to adult patients

Patients are managable in condition of decompesated shock if timely intervention is done.

Once the patient passes into irreversible shock it is very very difficult to revive and mortality is very high

How to recognise a patient clinically in a state of shock

STATE OF STABLE HEMODYNAMICS

Patient has clear consciousness

Periphery is warm and pink

Capillary refill time is 2 seconds or less

Pulse volume is good on palpation

Blood pressure is normal( between 5th to 95th centile for the age

Respiratory rate in the normal range for the age

Heart rate in the normal range for the age

Urine output normal for the age,1ml /kg/hour

STATE OF COMPENSATED SHOCK

Conscioussness inact

Periphery cool

Peripheral pulse ,low volume or thready

Capillary refill time more than 2 seconds

Blood pressure ,systolic is normal but diastolic is in rising trend,postural hypotension,narrow pulse pressure

Heart rate increased for the age

Respiratory rate increased for the age

Urine output reduced

STATE OF DECOMPENSATED SHOCK

Conscioussness-Restlessness or the patient is combative

Periphery on touch is cold and clammy

Capillary refill time is very prolonged like 5 seconds or more with or without mottling of skin

Peripheral pulse is very weak or may not be palpable at all even with great effort

Blood pressure -Hypotension,pulse pressure is 20 mm or less.Blood pressure may not be recordable

Heart rate-increased and in late stage decreased

Respiratory rate-Hyperpnea or Kussmaul breathing pattern(deep and sighy)

Urine output-oliguria or anuria

NORMAL RANGE of Respiratory rate

Premie-40-70/minute

0-3 months-30-60/minute

3-6 months-30-45/minute

6-12 months-25-40/minute

1-3 years-20-30/minute

3-6 years-20-25/minute

6-12 years-14-22/minute

>12 years 12-18/minute

NORMAL RANGE of heart rate- per minute

Premie 120-170

0-3 months 110-160

3-6 months 100-150

6-12 months 90-130

1-3 years 80-125

3-6 years 70-115

6-12 years 60-100

>12 years 60-100

HYPOTENSION is called when systolic blood pressure is below

60mm of Hg in NEW BORN,

70 mm of Hg between the age of 1 month to 1 year

70 mmHg+age in years multiplied by 2 ,between the age of 1- 10 years

90 mm Hg above the age of 10 years

Hypotension is also called when mean arterial pressure (MAP)is below 40+age in years multiplied by 1.5

MANAGEMENT:Management should start at the earliest, at the stage of compensated shock

First attention should be on airway and breathing and oxygen should be given if required to keep SPo2 95% and above

Life saving -for the circulation to be maintained, is fluid therapy

20 ml/kg of N/S or R/L shuold be given over 5-15 minutes and it should be pushed.It can be repeated twice if hydration,circulation and perfusion is not adequate.

In the settings of obvious fluid loss like diarrhoea ,vomiting or hemorrhage ,repeated fluid administration should be done till the signs of fluid overload develop, in the form of tachycardia,bilateral deep inspiratory crackles over subscapular region,liver enlargement,engorgement of jugular vein or signs of pulmonary edema on chest X-Ray

R/L shuold not be used in case of a history of repeated vomiting

IV bolus should be repeated ,only when there is sign of improvement clinically and no sign of fluid overload.

Aggressive fluid therapy may be harmful and should not be given in certain situations like shock in the settings of severe acute malnutrition,severe anemia,compensated shock with high fever with no dehydration or obvious fluid loss(Dengue fever),cardiogenic shock(ductal dependent congenital heart disease in newborn),obstructive shock(tension pneumothorax,cardiac temponade,)

SIGHNS OF CARDIOGENIC SHOCK-Tachycardia,engorged jugular vein,bilateral deep inspiratory crackles over subscapular regions,gallop rhythm,liver enlargement,signs of pulmonary edema on chest X-Ray.

In these cicumstances,crystalloids(N/S or R/L) should be given in the dose of 5-10 ml per kg over 15-30 minutes once then switch over to vasopressors

In case of poor response or no response to fluid therapy,swith over to vasopressures without delay.

If the periphery is cold,give DOPAMINE/EPINEPHRINE

If the perphery is warm give NORADRENALINE

In case of myocardial dysfuntion with maintained blood pressure,give DOBUTAMINE

In case of myocardial dysfuntion with increased peripheral resistance,use MILRINONE

Easy preparation and administration of vasopressures

Dopamine/Dobutamine 6 mg/kg-dilute in 100 ml of D5-1 ml/hour of this will deliver 1 mcg/kg/minute=Dose is 5-20 mcg/kg/minute

EPINEPHRINE0.6mg/kg of body weight,dilute in 100 ml of D5-1ml/hour will deliver 0.1mcg/kg/minute=Dose 0.05 to 0.2mcg/kg/minute,in severe cases upto 1mcg/kg/minute

Norepinephrine 0.6 mg/kg,dilute in 100 ml D5,1ml/hour will deliver 0.1mcg/kg/minute=Dose 0.1-1mcg/kg/hour

REFERENCES1.;Harriet Lane 21 edition

2. CDC guideline on management of shock in children

3.Uptodate-management of shock in children,2021

Air Pollution increases Pneumonia in children,Dr.Dev,M.D.,Pediatrician and Pediatric Pulmonologist,Rajendra Nagar Ghaziabad

In the period of October-November 2021 ,there is high level of air pollution in Delhi and NCR.
Air pollutants contain particulate matters of different sizes.
Pollutants containing sizes PM2.5 and PM10 are very dangerous.
These pollutants of size pm2.5 and pm10 can enter the respiratory tract of children.
PM 2.5 can easily enter the alveoli and damages it.
High pm2.5 was defined as pm2.5 level more than 10.75 mcg/cubic meter.
In one study published online on 29.10.2021 in Experimental biology and Medicine,out 810 children,220 were included in study and they were divided into two groups,one with high risk group for community acquired pneumonia(126 children) and second group with low risk for community acquired pneumonia(94).Pneumonia was defined by radiographic evidence of opacity consistent with pneumonia.
It was observrd that more cases of pneumonia were diagnosed from the area with high pm2.5 as compared to low pm2.5
The mean level of pm2.5 was 10.75mcg per cubic meter during study period which is lower than the high level set by U.S.Environmental protection agency .
According to the reports by SAFAR(System of air quality forecast and resaearch) Delhi,NCR,the highest level of pollutants including pm2.5,pm10,ovc,so2,co,nitric oxide are being seen in Delhi NCR air between midnight and 10 am in the morning as on 19.11.2021.Air quality index is in very poor category in Delhi,NCR as on 19.11.2021
So, air pollution is a risk factor for pneumonia in children

REFERENCES;1.. Mehta S, Shin H, Burnett R, North T, Cohen AJ. Ambient particulate air
pollution and acute lower respiratory infections: a systematic review
and implications for estimating the global burden of disease. Air Qual
Atmos Health 2013;6:69–83

2. Ostro B, Roth L, Malig B, Marty M. The effects of fine particle components on respiratory hospital admissions in children. Environ Health
Perspect 2009;117:475–80

Molnupiravir,approved for COVID treatment,may be a wonder drug,Dr.Dev,M.D.,Pediatrician and Pediatric Pulmonologist,Mohan Nagar,Ghaziabad,Delhi NCR

UK has become the first country in the world to approve MOLNUPIRAVIR for the treatment of Corona Virus Disease
It is an antiviral drug
It has been approved to treat mild to moderate disease with at least one risk factor for severity like obesity,Diabetes Mellitus,Heart disease
It should be given as early as the disease get detected and within five days of onset of symptoms
It is given twice daily for five days
It acts by altering the genome of virus and rendering the virus ineffective ,at the same time causing no harm to host
In animal study,it has been found to be safe
It is administered orally
It may be a wonder drug with capacity to change the game as the management till now is focussed on vaccine prevention of the disease and currently available antiviral drug Remdesivir is not much effective
REFERENCES;AFP NOVEMBER 05,2021

Cough and cold medicines are killing children,Dr.Dev,M.D.,Pediatrician and Pediatric Pulmonologist,Mohan Nagar,Ghaziabad,Delhi NCR

Cough and cold are the most frequent symptoms seen in children
It has become a trend to keep medicines at home for cough and cold
Many Parents are in habit of giving self medications to their children without any knowledge of dose and frequency of admininstration
Moreover,the dose of medicines keeps on changing in children unlike in adults
Parents are giving cough and cold medications for other purposes also like while air travelling to sedate the baby.
Cough and cold medications containing DIPHENHYDRAMINE ,when given in excessive doses,act as stimulants rather than sedatives.
The preparation containing DIPHENHYDRAMINE has killed many children.
There is evidence that these medications do not lessen the severity or duration of cough and cold.
Maximum deaths have occured in children below 2 years of age
In many homes,children easily access these medicines
THESE MEDICINES SHOULD NEVER BE PRESCRIBED IN CHILDREN BELOW 2 YEARS OF AGE
REFERENCES:Pediatrics: “Pediatric Fatalities Associated With Over-the-Counter Cough and Cold Medications,” “Pediatric Poisoning Fatalities: Beyond Cough and Cold Medications.

How to differentiate Dengue fever from MIS-C,Dr.Dev,M.D.,Pediatrician and Pediatric Pulmonologist ,Mohan Nagar,Ghaziabad,Delhi NCR

Severe Dengue fever and Multisystem inflammatory syndrome in children(MIS-C) both are the states of cytokine storm

Both these conditions present almost similarly,clinically

In the period of September-October 2021 both disease conditions are being seen frequently in India

Severe Dengue fever is caused by Dengue virus ,transmitted into human through Aedes mosquito bites

MIS-C is a post COVID 19 state

It is very important to differentiate between these two conditions for the treatment purposes as the treatment of these two are entirely different
In cases of severe Dengue fever the mainstay of treatment is aggressive fluid therapy with crystalloid ,colloid and when needed ionotrops and platelet transfusion if severe thrombocytopenia.
In contrast,aggressive fluid therapy may be life threatening in MIS-C,in which there may be left ventricular dysfunction.In this condition, the mainstay of treatment is intravenous steroid with or without IVIG.Other medications required are low molecular heparin and aspirin.

If there is fever with prominent vomiting,myalgia,erthmatous rashes,profound weakness and on investigations there is leucopenia,severe thrombocytopenia,hemoconcentration and raised serum Ferritin,it is indicative of severe Dengue fever. Positive NS1 antigen and or IgM antibody for Dengue virus confirms the diagnosis
If there is conjuntival injections,swelling of hands and feet,altered sensorium and diarrhoea along with fever, and on investigations leucocytosis,fibrogienemia,raised serum D-Dimer,raised serum IL6 ,it is leading towards the diagnosis of MIS-C. Positive RT-PCR or antibody againt COVID 19 confirms the diagnosis.

REFERENCES:1.Indian Pediatrics:volume 58;15 october 2021
2. Ahmed M, Advani S, Moreira , et al. Multisystem
inflammatory syndrome in children: A systematic review. E
Clin Med. 2020;26:100527.
3. Mishra S, Ramanathan R, Agarwalla SK. Clinical profile of
dengue fever in children: A study from southern Odisha,
India. Scientifica (Cairo). 2016;2016:6391594.

Dengue fever/MIS-C,DR D.K.JHA,M.D.,Pediatrician and Pediatric Pulmonologist Delhi

In the period of october 2021,both Dengue fever and Multi system inflammatory syndrome in children(MIS-C) are being seen in children in Delhi,India

Clinical and laboratory features are overlapping for both these diseases

It is important to differentiate between these as management entirely differs for both

In case of Dengue fever the cornerstone of management is aggressive fluid therapy with crystalloid and colloid with ionotrops if fluid therapy does not work and platelet transfusion if needed.

In cases of MIS-C, the cornerstone of management is steroids and IVIG(Immunoglobulins).Aggressive fluid management may be detrimental in cases of shock with cardiac dysfunction.

Fever are common in both but swellings of feet and hands,diarrhoea,conjuntival injections and altered sensorium along with the laboratory findings of hyperinflammation like highly raised CRP,Leukocytosis,raised D-Dimer are pointers towards MIS-C .In this situations,anti COVID antibody should be done and if positive ,confirms the diagnosis of MIS-C

If fever is associated with vomiting ,erythmatous rashes,myalgia along with the laboratory findings of leucopenia ,severe thrombocytopenia,hemoconcentration , raised serum ferritin level,it points towards the diagnosis of Dengue fever and NS1 antigen and or anti Den IgM should be done which when positive confirms the diagnosis of Dengue fever

In comparision to MIS-C,serum Ferritin level is higher in Dengue fever

References:

1. Ahmed M, Advani S, Moreira A, et al. Multisystem
inflammatory syndrome in children: A systematic review. E
Clin Med. 2020;26:100527.

2.Mishra S, Ramanathan R, Agarwalla SK. Clinical profile of
dengue fever in children: A study from southern Odisha,
India. Scientifica (Cairo). 2016;2016:6391594

3.Indian Pediatrics,volume 58,15 October,2021

Large population of Delhi NCR children have ASTHMA.Dr.Dev,MD,Pediatrician and Pediatric Pulmonologist,Ghaziabad,Delhi NCR

Delhi is among most polluted cities in the world
Air pollution directly affects lung
Lungs of children are most vulnerable as the lungs are growing.
Children breath in more air than adults due to fast respiratory rate as compared to adults
Particulate matters in air particularly PM10 and PM2.5 can enter the airways and PM2.5 can go into alveoli
The level of PM10 and PM2.5 are 15 times higher in Delhi air as compared to set standard by World Health Organisation
The pollutants in air comprise obesogenic compounds responsible for making a child Obese
Obesity is associated with the development of Asthma in children
According to a cross sectional study done in 3 cities in India including the most polluted city Delhi and 2 less polluted cities in South India-Kottayam and Mysore, Published in LUNG INDIA September-October 2021,approximately 30% children in Delhi are suffering from Asthma.
Almost 50% children reported cough and 30% complained of shortness of breath.
Among 4361 children studying in private schools between the ages of 13-14 and 16-17,boys and girls, 3157 successfully completed the ISAAC Questionnaire and performed spirometry.
On the basis of spirometry ,which shows airway obstruction, a diagnostic component of Asthma,almost 30% children were diagnosed as having ASTHMA.
Most of the parents and children are not aware of this disease in children.
They are not easily accepting the diagnosis of ASTHMA in children, but it is a fact and we should do something proactively to control the level of pollution in cities to control the ASTHMA
The study has been published in LUNG INDIA September-October,2021

REFERENCES;. Singh V, Singh S, Biswal A. Exceedances and trends of particulate matter (PM2.5) in five Indian megacities Sci Total Environ. 2021;750:141461
Cited Here | PubMed | CrossRef
2. Central Pollution Control Board, Ministry of Environment, Forest and Climate Change. National Ambient Air Quality Status and Trends. 2019 Available from: https://cpcb.nic.in/upload/NAAQS_2019.pdfLast accessed on 2020 Oct 28
Cited Here
3. The Lancet Planetary Health. . Government indifference over air pollution crisis in Delhi

UPCOMING WAVE OF COVID-19 and Children,Dr.Dev,M.D.,Pediatric Pulmonologist,Ghaziabad,Delhi NCR

The coronavirus disease and or infection has affected all age group of individuals all over the world.
The herd immunity ,means immunity of entire population of an area to fight any disease develops naturally when almost 70% population of that area is infected .
The other way to develop immunity against the disease is,vaccination of the entire population.
It has been in discussion in India for last couple of weeks that,the upcoming wave of COVID-19 will affect only children and there will be large number of deaths among children.
It has been observed till now all over the world that children have been affected lees and mortality has been less as compared to adults.
But fear among parents and among doctors is genuine.
There are two reasons for that.
1. Since the adult population has been widely covered by vaccination,they will either have no disease or less severe disease.Children are left unvaccinated till now ,so the infection will cause various degrees of diseases in children.
2.Although the mortality percentage is less in children as compared to adults,a large population of diseased children will put burden on health care system and as the number of diseased children will be more,there will be less medical care and high mortality
REFERENCES:Interview given by Dr. Bhramar Mukharjee,Professor and chair of biostatistics,Michigan school of Public health,published in TOI,Delhi edition,Friday,25.06.2021

WATCH DR.DK.JHA,M.D.,Pediatric Pulmonologist and Respiratory intensivist ,Delhi, moderating a Panel discussion by international experts on Asthma in children with or without COVID 19

The most common chronic respiratory disease from which children all over the world suffer is ASTHMA.

Please click to know more for the better care of asthmatic children.

https://m.facebook.com/story.php?story_fbid=1406721312822521&id=412160705929917?sfnsn=wiwspwa&extid=jHdMecjhkGPw6XDM&d=w&vh=e

PANEL DISCUSSION ON ASTHMA IN CHILDREN WITH OR WITHOUT COVID 19,by Experts,moderated by Dr.Dev,M.D,Pediatric Pulmonologist and Respiratory intensivist ,Delhi ncr

https://m.facebook.com/story.php?story_fbid=1406721312822521&id=412160705929917?sfnsn=wiwspwa&extid=jHdMecjhkGPw6XDM&d=w&vh=eAsthma is the most common chronic respiratory disease in children worldwide.
It is being discussed by international experts.Please click below

https://m.facebook.com/story.php?story_fbid=1406721312822521&id=412160705929917?sfnsn=wiwspwa&extid=jHdMecjhkGPw6XDM&d=w&vh=e

https://m.facebook.com/story.php?story_fbid=1406721312822521&id=412160705929917?sfnsn=wiwspwa&extid=jHdMecjhkGPw6XDM&d=w&vh=e
This is being published here to update the knowledge of doctors treating asthmatic child.
It should be translated into the better care of asthmatic children all over the world.